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Lewis a antigen in transitional cell tumors of the urinary bladder
Author(s) -
Juhl Birgitte Ravn,
Hartzen Susanne Hartvig,
Hainau BO
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860715)58:2<222::aid-cncr2820580204>3.0.co;2-r
Subject(s) - medicine , urothelium , antigen , urinary bladder , bladder cancer , population , pathology , urinary system , immunoperoxidase , transitional cell carcinoma , stage (stratigraphy) , urology , monoclonal antibody , antibody , cancer , immunology , biology , paleontology , environmental health
The failure of A,B,H antigens as prognostic parameters in noninvasive bladder cancer of blood group O individuals, who constitute 44% of the population, encouraged the evaluation of the closely related Lewis a antigen. Ninety‐three tumors of the urinary bladder were stained employing the Tween 20 (Merck)‐ modified immunoperoxidase staining technique and serial dilution of monoclonal anti‐Lewis a antibodies. On the basis of recent findings in non‐neoplastic ureter urothelium of erythrocyte Le a+b− , Le a‐b+ , and Le a‐b− individuals, alterations in tumors, except eight from Le a‐b− individuals, were quantified on a scale from 0 (normal) to 3 (total loss). Scores were related to the pathologic stage and grade ( P < 0.01), and, in stage P, tumors, to the clinical course: recurrence rate ( P < 0.10), stroma invasive recurrence, and/or papillomatosis ( P < 0.05). Although further studies are needed the current study points to Lewis a antigen determination as an advantageous prognostic tool in stage P a tumors of the urinary bladder of Le a‐b+ and Le a+b− individuals, who, together, constitute 94% of the population. Cancer 58:222–228, 1986.