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Immunologic alterations in xeroderma pigmentosum patients
Author(s) -
Wysenbeek Arjeh J.,
Weiss Haya,
DuczyminerKahana Malka,
Grunwald Marcello H.,
Pick Albert I.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860715)58:2<219::aid-cncr2820580203>3.0.co;2-a
Subject(s) - xeroderma pigmentosum , medicine , immunology , photodermatosis , lymphocyte , delayed hypersensitivity , lymphocyte activation , skin reaction , hypersensitivity reaction , dermatology , dna repair , dna , antigen , immune system , genetics , t cell , biology
Nine xeroderma pigmentosum (XP) patients were investigated. In comparison to a normal control group the XP patients had a reduced OKT‐4 lymphocyte subpopulation, reduced response of lymphocytes to phytohemagglutinin in autologous serum, and diminished delayed hypersensitivity skin reaction. The possible contribution of ultraviolet irradiation to the observed immunologic alterations, and the link of these alterations to the susceptibility of patients for malignant transformation is discussed. Cancer 58:219–221, 1986.