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The relation of susceptibility to and biologic behavior of thyroid epithelial cell cancer to HLA‐DR1
Author(s) -
Juhasz Ferenc,
Balázs Gyorgy,
Stenszky Valeria,
Kozma Laszlo,
Farid Nadir R.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860701)58:1<52::aid-cncr2820580110>3.0.co;2-3
Subject(s) - medicine , human leukocyte antigen , thyroid cancer , histocompatibility , thyroid , major histocompatibility complex , cancer , disease , immunology , oncology , antigen
Fifty‐two patients with thyroid epithelial cell cancer were studied for evidence of association with human leukocyte antigens (HLA). Twenty‐eight patients (53.8%) and 19.4% of 160 controls were HLA‐DR1‐positive, conferring a relative risk of 4.85 ( x 2 = 21.3, P < 0.0001). HLA‐DR1 was increased in all histologic types of thyroid cancer. Interestingly 10 of 12 patients with metastatic disease were DR1‐positive compared to 18 of 41 patients without metastases (relative risk = 6.1, x 2 = 4.7, P < 0.05). This study suggests that major histocompatibility complex‐linked gene(s) determine susceptibility to and the biologic behavior of thyroid cancer. Cancer 58:52–54, 1986.