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Lung cancer detection results of a randomized prospective study in Czechoslovakia
Author(s) -
Kubík A.,
Polák J.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860615)57:12<2427::aid-cncr2820571230>3.0.co;2-m
Subject(s) - medicine , lung cancer screening , lung cancer , population , cancer , stage (stratigraphy) , incidence (geometry) , prospective cohort study , surgery , paleontology , physics , environmental health , biology , optics
A randomized prospective study of lung cancer detection was begun in 1976 to evaluate semiannual screening by radiologic and sputum cytologic study in comparison to screening at a 3‐year interval, and to no screening. In a high‐risk population of 6364 men (aged 40 to 64 years), the initial prevalence of lung cancer was 0.28% (18 cases), the annual incidence was 0.35% per year (66 cases during 3 years), the proportion of Stage I cases was 31% (26/84), and Stage II was 17% (14/84), “curative” resections were 27% (23/84), and 5‐year survival was 23% (19/84). The study confirmed the ability of radiologic screening to detect lung cancer at an earlier stage when treatment by resection can be accomplished. The fate of a high‐risk population submitted to screening was better than that of a population with no screening where lung cancer was discovered by symptoms, accidental x‐rays, or at autopsy. A matter of lesser importance was the frequency of screening. The absolute numbers of 5‐year survivors detected by screening were practically the same for either compared screening frequency. Cancer 57:2427–2437, 1986.