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DNA content and prognosis in renal cell carcinoma. A comparison between primary tumors and metastases
Author(s) -
Ljungberg Börje,
Stenling Roger,
Roos Göran
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860615)57:12<2346::aid-cncr2820571218>3.0.co;2-4
Subject(s) - medicine , renal cell carcinoma , dna , pathology , primary (astronomy) , cancer research , oncology , biology , genetics , physics , astronomy
Deoxyribonucleic acid (DNA) content was retrospectively determined by single‐cell cytophotometry in primary tumors and corresponding metastases from 32 patients with renal cell carcinoma. In 15 of the primary tumors a diploid/near diploid and in 17 an aneuploid DNA content was found. A diploid/near diploid DNA pattern was revealed in 10 metastases and 22 were aneuploid. By comparing the DNA content in the primary tumors with their metastases, 13 of 32 showed a clear divergency, which might illustrate tumor cell heterogeneity of renal cell carcinoma. The DNA pattern showed a close correlation to morphologic grading. A correlation between DNA content in the metastases and survival time was found. Patients, with diploid/near diploid metastases survived significantly longer than those with aneuploid DNA contents (mean, 31.1 and 11.5 months, respectively; P = 0.004). In contrast to this, no correlation was found between DNA content in the primary tumors and survival time. Cancer 57:2343–2350, 1986.