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Diagnostic value of high molecular weight alkaline phosphatase in detection of hepatic metastasis in patients with lung cancer
Author(s) -
Nishio Hiroshi,
Sakuma Takahiko,
Nakamura ShinIchiro,
Horai Takeshi,
Ikegami Harumichi,
Matsuda Minoru
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860501)57:9<1815::aid-cncr2820570918>3.0.co;2-1
Subject(s) - alkaline phosphatase , metastasis , medicine , lung cancer , lung , cancer , pathology , elevated alkaline phosphatase , carcinoma , gastroenterology , enzyme , biology , biochemistry
High molecular weight alkaline phosphatase (HMW‐ALP) was measured in the sera of 126 patients with lung cancer to determine its diagnostic value in the detection of hepatic metastasis. This isoenzyme was found in 21 of 24 patients with hepatic metastasis and in 27 of 102 patients without hepatic metastasis. When 10 U/L was used as a cut‐off value, the sensitivity, specificity, and accuracy of this test were 71%, 89%, and 86%, respectively. From the standpoint of histologic type, this test was most useful in patients with small cell carcinoma. HMW‐ALP was not detected in the sera of 15 controls. It is concluded that HMW‐ALP is a useful marker for hepatic metastasis in patients with lung cancer.