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Conservative treatment (chemotherapy/radiotherapy) of locally advanced breast cancer
Author(s) -
Héary Michel,
Namer Moise,
Moro Michel,
Boublil JeanLouis,
Lalanne Claude M.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860501)57:9<1744::aid-cncr2820570906>3.0.co;2-b
Subject(s) - medicine , radiation therapy , cosmesis , chemotherapy , breast cancer , vincristine , cyclophosphamide , mastectomy , surgery , mammary gland , subclinical infection , doxorubicin , oncology , cancer
Once treated almost exclusively by radical surgery, locally advanced breast cancers (Stages III, IV; MO) were later treated solely by irradiation, but local results (cosmesis and recurrences) remained poor. Since 1977, we have used induction chemotherapy in an attempt to treat subclinical metastatic disease while allowing better quality mammary conservation in a greater number of patients. From 1977 to 1980, 25 patients (Stages III, IV; MO) were treated by a sequential association of chemotherapy (Adriamycin [doxorubicin], vincristine, cyclophosphamide, 5‐fluorouracil; 3 cycles) followed by irradiation (45 Gy to the breast and nodal areas; 15–30 Gy mammary boost dose). Responses of 50% or more were observed in 86% of the breast lesions and in 80% of nodal lesions. This sequential treatment was always well tolerated. Local recurrences occurred in six patients (24%) who underwent mastectomy without any complications. The survival rate at 4 years is 55%.