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Prognostic factors in adenocarcinoma of the uterine cervix
Author(s) -
Saigo Patricia E.,
Cain Joanna M.,
Kim Woo Shin,
Gaynor Jeffrey J.,
Johnson Katherine,
Lewis John L.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860415)57:8<1584::aid-cncr2820570825>3.0.co;2-8
Subject(s) - medicine , stage (stratigraphy) , adenocarcinoma , adenosquamous carcinoma , cervix , cancer , asymptomatic , carcinoma , lymph node , gastroenterology , pathology , gynecology , oncology , paleontology , biology
Abstract A group of 136 female patients with adenocarcinoma of the uterine cervix, treated at Memorial Sloan‐Kettering Cancer Center between 1949 and 1981, with slides available for review, formed the basis for this study. They ranged in age from 10 to 91 years. Most (73%) had abnormal bleeding, either alone or in combination with other symptoms; 15% were asymptomatic. Eighty percent had a visible abnormality, most commonly an exophytic mass. Clinical stages were: 0 (3%), IB (61%), IIA (14%), IIB (10%), III (4%). There were four major histologic subtypes: mucinous (47%), endometrioid (24%), adenosquamous (15%), and clear cell (9%) carcinoma. Of the many clinicopathologic variables evaluated for prognosis, the most significant was stage of disease ( P < 0.0001). Those with Stage IB disease had a survival probability of 76% at 5 years compared with 49% for those with Stage IIA and 34% with Stage IIB. The endometrioid pattern was associated with a more favorable prognosis than any other histologic subtype ( P = 0.02). The presence of lymphatic tumor emboli and/or metastatic carcinoma in any lymph node group was associated with a less favorable prognosis for patients with Stage IB and IIA disease ( P < 0.0001). Cancer 57:1584–1593, 1986.