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Progesterone receptors in two groups of endometrial carcinoma
Author(s) -
Deligdisch Liane,
Holinka Christian F.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860401)57:7<1385::aid-cncr2820570724>3.0.co;2-v
Subject(s) - medicine , carcinoma , endometrial cancer , stromal cell , atypical hyperplasia , estrogen , estrogen receptor , endometrial hyperplasia , pathology , oncology , cancer , breast cancer
A previous study evaluated two types of endometrial carcinoma: one withthe other withoutassociated adenomatous hyperplasia (Groups 1 and 2respectively). On the basis of histologic observationsthe study concluded that Group 1 tumors were likely to be estrogen‐dependentwhereas Group 2 tumors appeared to represent a hormone‐independent type of cancer. The authors present quantitative biochemical data to support the proposition that Group 1 tumors are likely to be under the influence of estrogen. Progesterone receptor levelsknown to be increased by estradiolwere significantly higher in Group 1 than in Group 2. Analysis of histologic variants revealed that some histologic componentssuch as mucinous adenocarcinomasquamous componentsand stromal foam cellspredominated in Group 1 and maythereforebe indicative of estrogen action. Certain histologic featureshoweversuch as papillary carcinomaclear cellsand anaplastic carcinoma with giant tumor cellswere found exclusively in Group 2thus suggesting a lack of estrogenic influence. These findings indicate that Group 1 and Group 2 endometrial carcinomas may constitute two different biologic entities andthusencourage further basic and clinical research to develop specific therapies for patients diagnosed to have endometrial cancer.