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Lymphadenopathy due to fatal histiocytic proliferative disorder containing michaelis‐gutmann bodies
Author(s) -
Dervan Peter A.,
Teeling Mary,
Dempsey James,
Drury Ivo M.,
O'Malley Eoin,
O'Connell Denis
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860401)57:7<1337::aid-cncr2820570715>3.0.co;2-s
Subject(s) - histiocyte , pathology , lymph node , immunohistochemistry , medicine , lymph , lymphoma , generalized lymphadenopathy
A 59‐year‐old white man had generalized lymphadenopathyfeverweight lossand hypercalcemia. Histologic examination of seven lymph nodes from three different anatomic sites revealed a diffuse histiocytic infiltrate containing numerous typical Michaelis‐Gutmann (MG) bodies. Histochemical and immunohistochemical results confirmed the histiocytic nature of the predominant cell within the infiltrate. Approximately equal numbers of residual normal B‐cells T‐helperand T‐suppressor cells were present. Electron microscopy revealed extracellular and intracellular MG bodiesmany of which were membrane‐bound. Special stainselectron microscopyand lymph node culture did not demonstrate microorganisms. The histologic features of the infiltrate were those of malacoplakia. Howeverthe disease behaved like a lymphomawith the occurrence of lymphadenopathy and a fatal outcome.