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Gonadal tumor and H‐Y antigen in 46,XY pure gonadal dysgenesis
Author(s) -
Amice VÉRonique,
Amice Jean,
Bercovici JeanPierre,
Riviere Denise,
Corolleur MarieJoséa
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860401)57:7<1313::aid-cncr2820570710>3.0.co;2-k
Subject(s) - medicine , gonadal dysgenesis , antigen , endocrinology , gynecology , immunology
Six cases of Swyer's syndrome (46,XY pure gonadal dysgenesis) are reported. Three patientswithout gonadal tumorhad female H‐Y antigen. Three patientsafter gonadal tumor ablationhad intermediate H‐Y antigen levels. Repeated blood samples were obtained from two siblings. H‐Y antigen level in the first siblingwho presented with a gonadoblastoma and underwent a gonadectomy before the H‐Y assayswas intermediateand did not show any significant variation for 21 months. H‐Y antigen level in the second sibling showed an increase in the male rangepresumably due to the presence of gonadoblastomas. After resection of the tumors H‐Y antigen level became intermediate. These findings suggest a relation between the tumorization potentiality of the gonadal remnants and the H‐Y antigen levels in 46,XY pure gonadal dysgenesis.