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8;14 chromosome translocation in a negative bone marrow aspirate from a patient with Burkitt's lymphoma
Author(s) -
Richardson Leslie A.,
Dickerman Joseph D.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860215)57:4<761::aid-cncr2820570413>3.0.co;2-c
Subject(s) - chromosomal translocation , medicine , bone marrow , lymphoma , bone marrow aspirate , chromosome , pathology , presentation (obstetrics) , burkitt's lymphoma , cancer research , surgery , biology , genetics , gene
A patient with Burkitt's lymphoma is described who, on presentation, had a bone marrow aspirate which did not show abnormal cells. Cells from the bone marrow were cultured and an 8;14 chromosome translocation was identified. This finding allowed us to upgrade the stage of disease from III to IV with therapeutic as well as prognostic implications.