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N 1 ‐(2 tetrahydrofuryl)‐5‐fluorouracil (ft‐207) in the postoperative adjuvant chemotherapy of gastric cancer. Delivery of a fat‐emulsified agent to the lymph
Author(s) -
Hanaue Hitoshi,
Kurosawa Tsutomu,
Kitano Yoshiaki,
Miyakawa Sadaaki,
Horie Fumitoshi,
Nemoto Akihisa,
Shikata JunIchi
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860215)57:4<693::aid-cncr2820570402>3.0.co;2-a
Subject(s) - medicine , lymph , fluorouracil , cancer , chemotherapy , adjuvant chemotherapy , gastroenterology , surgery , pathology , breast cancer
The influence of fat emulsification of N 1 ‐(2‐tetrahydrofuryl)‐5‐fluorouracil (FT‐207) on lymphatic transport was studied in seven postoperative gastric cancer patients. The water‐in‐oil‐type of emulsion of FT‐207 (FT‐w/o), the oil‐in‐water‐type emulsion of FT‐207 (FT‐o/w) and an enteric‐coated granule of FT‐207 (FT‐G) each in 1‐g doses, calculated in terms of FT‐207, were administered orally. Lymph from a thoracic duct fistula, prepared in advance, and from the blood of a peripheral vein was collected simultaneously along a time course after administration to measure the concentrations of FT‐207 and 5‐fluorouracil (5‐FU). For FT‐w/o, FT‐207, and 5‐FU, concentrations were significantly higher, both in the lymph and in the blood, than those for FT‐G and FT‐o/w. However, no significant differences in FT‐207 and 5‐FU concentrations were observed between FT‐o/w and FT‐G. It was concluded that FT‐w/o can be useful as an adjuvant chemotherapeutic drug in the postoperative treatment of gastric cancer.