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Atypical fibroxanthoma of the skin with metastasis
Author(s) -
Helwig Elson B.,
May Dennis
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860115)57:2<368::aid-cncr2820570230>3.0.co;2-n
Subject(s) - atypical fibroxanthoma , medicine , metastasis , head and neck , pathology , nodule (geology) , parotid gland , immunohistochemistry , cancer , surgery , biology , paleontology
Cutaneous atypical fibroxanthoma (AFX) occurs in elderly persons as a small nodule or ulceronodule in actinically damaged skin of the head and neck area. The vast majority of AFX behave in a benign manner, and metastasis is rare. Eight examples of metastasizing AFX are reported. Factors that portend agressive behavior and metastasis are vascular invasion, recurrence, deep tissue invasion, tumor necrosis and, possibly, defective or depressed host resistance. The metastasizing primary AFX were located on the head, and the metastasis involved the structures in the region of the parotid gland.