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Primary squamous cell carcinoma with its spindle cell variant in the endometrium. A case report and review of literature
Author(s) -
Yamashina Motoaki,
Kobara Thomas Y.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860115)57:2<340::aid-cncr2820570225>3.0.co;2-z
Subject(s) - medicine , pyometra , pathology , endometrium , basal cell , carcinoma , cell , squamous metaplasia , malignant transformation , epithelium , biology , uterus , genetics
A case of squamous cell carcinoma of the endometrium in a 72‐year‐old woman is presented. A review of the previous 28 cases of endometrial squamous cell carcinoma (ESCC) that are adequately substantiated in the literature revealed several misconceptions about this rare tumor: the association with pyometra is not as frequent; the lesion does occur in premenopausal women; squamous metaplasia of the endometrium is not always coexistent; and malignant transformation of squamous metaplasia to ESCC has never been convincingly demonstrated. In the current case, a focal sarcomatoid spindle‐cell tumor was associated with typical ESCC; however, light and electron microscopic examinations provided convincing evidence that the tumor was composed solely of ESCC. Ultrastructure of the spindle‐cell tumor revealed it to be essentially identical to that of a spindle‐cell variant of squamous cell carcinoma reported previously.