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Mitoxantrone, methotrexate, and 5‐fluorouracil combination chemotherapy as first‐line treatment in stage IV breast cancer
Author(s) -
Bezwoda Werner R.,
Hesdorffer Charles S.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860115)57:2<218::aid-cncr2820570205>3.0.co;2-j
Subject(s) - medicine , mitoxantrone , fluorouracil , leukopenia , chemotherapy , methotrexate , nausea , breast cancer , combination chemotherapy , stage (stratigraphy) , surgery , oncology , cancer , phases of clinical research , gastroenterology , paleontology , biology
Fifty patients with Stage IV breast cancer were entered into a prospective Phase II trial of combination chemotherapy that consisted of mitoxantrone (10 mg/m 2 ), methotrexate (40 mg/m 2 ), and 5‐fluorouracil (600 mg/m 2 ) given in a 3‐weekly schedule. Objective response to treatment was seen in 18 of 48 assessable patients (38%). Responses were seen predominantly in the lung and pleura and the node and soft tissue sites of disease. The median duration of response was 7 months. Toxicity from treatment consisted predominantly of reversible leukopenia. Other toxicities such as nausea and alopecia occurred in less than one half of the patients in the study group. The combination was well‐tolerated, and appears to be moderately effective.