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The role of 13 cis‐retinoic acid in the remission induction of a patient with acute promyelocytic leukemia
Author(s) -
Fontana Joseph A.,
Rogers John S.,
Durham John P.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860115)57:2<209::aid-cncr2820570204>3.0.co;2-k
Subject(s) - acute promyelocytic leukemia , retinoic acid , medicine , leukemia , tretinoin , cancer research , myeloid leukemia , myeloid , cellular differentiation , immunology , cell culture , biology , biochemistry , genetics , gene
The addition of retinoic acid to human promyelocytic leukemia cells in culture results in their differentiation to mature myeloid forms with acquisition of the differentiated phenotype, i.e. , the ability to reduce nitroblue tetrazolium. A heavily pretreated patient with acute promyelocytic leukemia and residual malignant cells in his marrow after multiple courses of chemotherapy was given 13‐ cis ‐retinoic acid upon demonstration of both morphologic and functional differentiation of his leukemic cells by transretinoic acid in vitro . The patient achieved a complete remission and was maintained on 13‐ cis ‐retinoic acid for 1 year, when the patient relapsed with a population of cells that were resistant to retinoic acid‐induced differentiation.