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Successful non‐neurotoxic therapy (without radiation) of a multifocal primary brain lymphoma with a methotrexate, vincristine, and BCNU protocol (DEMOB)
Author(s) -
Cohen Ian J.,
Vogel Ruth,
Matz Shoshana,
Weitz Raphael,
Mor Celia,
Stern Sidi,
Zaizov Rina
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860101)57:1<6::aid-cncr2820570104>3.0.co;2-b
Subject(s) - medicine , carmustine , vincristine , methotrexate , regimen , neurotoxicity , radiation therapy , dexamethasone , lymphoma , chemotherapy , oncology , surgery , toxicity , cyclophosphamide
A 3.5‐year‐old boy with a multifocal primary lymphoma of the brain was treated successfully without neurotoxicity with a treatment regimen that did not include radiation. The protocol of Dexacort (dexamethasone), methotrexate, Oncovin (vincristine), and BCNU (carmustine) (DEMOB), which was developed with the use of MTX pharmocokinetic studies, was given over 7.5 months, and resulted in tumor disappearance on computerized tomography scans and marked improvement in clinical status. The patient remains in good health 3 years after diagnosis (March 1985).