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Improved survival in the treatment of advanced hodgkin's disease at a nonuniversity institution (1970–1979)
Author(s) -
Friedenberg William R.,
Dirks P.,
Beltaos E.,
Mazza J. J.,
Hoehn J. L.,
Greenlaw R. H.,
Russ H. H.,
Schloesser L. L.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860101)57:1<12::aid-cncr2820570105>3.0.co;2-f
Subject(s) - medicine , disease , institution , oncology , medical physics , political science , law
From 1970 through 1979, 89 patients with Hodgkin's disease were treated at the Marshfield Clinic/St. Joseph's Hospital. After the pathologic Material was reviewed, the patients were analyzed to compare Group I (1970–1973) with Group II (1974–1979). Demographic characteristics in the two groups were similar. In the decade, 76% of patients achieved complete remission. In advanced‐stage disease, 50% of patients achieved complete remission in Group I compared with 68% in Group II. At 5 years, 50% of patients were alive without COPP (cyclophosphamide, vincristine, procarbazine, prednisone) chemotherapy; with this treatment, 75% of patients survived ( P = 0.02). There was improved survival comparing Group I (56% at 5 years) with Group II (76% at 5 years) patients with advanced disease ( P = 0.004). More aggressive combination chemotherapy (COPP) was related to the improvement in survival ( P < 0.001). The advances in treatment Made by cooperative groups and universities are being transferred to nonuniversity institutions, with appropriate improvement in survival of Hodgkin's disease.