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Bone marrow transplantation for malignant histiocytosis in childhood
Author(s) -
Vowels Marcus R.,
LamPoTang Reg,
Mameghan Hedy,
Heller Edgar,
Ford David,
Ziegler John,
Hughes Darcy O'gorman
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19851215)56:12<2786::aid-cncr2820561212>3.0.co;2-e
Subject(s) - medicine , cyclophosphamide , malignant histiocytosis , total body irradiation , surgery , bone marrow , disease , histiocytosis , bone marrow transplantation , malignant disease , transplantation , chemotherapy , stage (stratigraphy) , pediatrics , pathology , cancer , histiocyte , paleontology , biology
This report describes a girl who was diagnosed with malignant histiocytosis at the age of 5 years. The disease was controlled initially with chemotherapy for 3 years and had then recurred with meningeal involvement on three occasions. Four years and 8 months from diagnosis, bone marrow transplantation (BMT) was undertaken from an HLA‐identical and mixed lymphocyte culture (MLC) nonreactive brother after conditioning with VP‐16‐213 5 mg/kg/day × 2, cyclophosphamide 60 mg/kg/day × 2, and total body irradiation 200 rad twice daily to a total dose of 1000 rad delivered at 7 rad/minute. At the time of transplant, the disease was in remission. Currently, more than 48 months after the transplant, the child remains free of disease, with a normally functioning donor marrow and with no evidence of graft versus host disease. This is the first recorded case of BMT in the treatment of malignant histiocytosis. The outcome in this patient in late‐stage disease suggests that BMT could be considered early in management as definitive therapy.