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Heterotransplantation of human cervix cancers in radiation‐conditioned or nonconditioned athymic mice
Author(s) -
Maruyama Yosh,
Feola Jose M.,
van Nagell John R.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19851201)56:11<2635::aid-cncr2820561117>3.0.co;2-l
Subject(s) - medicine , cervix , cancer research , virology , cancer
Primary human cervix cancers were implanted into athymic nude mice from 23 patient biopsy specimens. Tissue/tumor samples were implanted as chunks by trochar in different sites in irradiated (400 rad) or nonirradiated nude mice. Without irradiation 1 of 9 (11%) implanted tumors grew progressively and 13 of 26 (50%) implanted sites formed small implantation nodules that remained stable and usually regressed. In nude mice given 400‐rad irradiation, 3 of 12 (25%) showed progressive tumor growth, 8 of 12 (67%) patient samples showed growth, and 24 of 36 (67%) implanted sites showed growth. Correlation with clinical data showed that the higher‐stage and more malignant tumors were more likely to show progressive growth patterns, as was noted in three of five Stage III/IV cervix tumors grafted into 400‐rad conditioned mice. Conversely, the lower‐stage tumors were much less likely to show growth, and zero of nine samples with Stage I/II tumors showed progressive growth.