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Juvenile xanthogranuloma clinicopathologic analysis and immunohistochemical study of 57 patients
Author(s) -
Sonoda Takashi,
Hashimoto Hiroshi,
Enjoji Munetomo
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19851101)56:9<2280::aid-cncr2820560923>3.0.co;2-l
Subject(s) - medicine , juvenile xanthogranuloma , lesion , pathology , immunohistochemistry , trunk , differential diagnosis , involution (esoterism) , head and neck , juvenile , histiocyte , surgery , biology , ecology , consciousness , genetics , neuroscience
Fifty‐seven cases of juvenile xanthogranuloma that fulfilled the classic description of histologic findings of the disease were analyzed clinicopathologically and immunohistochemically. Two forms could be distinguished: 47 cases of the infantile form and 10 of the adolescent and young adult form. The infantile lesion was found at birth in 8 patients (17%), and was noted within 1 year after birth in 33 (70%). Twenty‐two had multiple lesions and five of the six for whom follow‐up was feasible had spontaneous involution. About half of the lesions were located on the head and neck, 30% on the trunk, and 20% on the extremities. All six adolescents had a solitary tumor located in the head and neck region. Comparison of the latter form with reticulohistiocytoma and cutaneous fibrous histiocytoma was established from a differential point of view. Immunohistochemically, most lesions of juvenile xanthogranuloma displayed a positive reaction for lysozyme and alpha‐1‐antichymotrypsin and were negative for S‐100 protein, thereby suggesting that the essential constituents of this lesion would derive from the mononuclear phagocyte system.