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Protein composition of cyst fluids from mature teratoma in patients with nonseminomatous germ cell tumors of the testis
Author(s) -
Ockhuizen Theo,
Veenstra Jan,
Suurmeijer Albert J. H.,
Fleuren Gert J.,
Koops Heimen Schraffordt,
De Bruijn Henk W. A.,
Sleijfer Dirk Th.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19851101)56:9<2264::aid-cncr2820560921>3.0.co;2-h
Subject(s) - carcinoembryonic antigen , cyst , ferritin , human chorionic gonadotropin , medicine , pathology , germ cell , lumen (anatomy) , oncofetal antigen , germ cell tumors , blood proteins , biology , biochemistry , cancer , hormone , chemotherapy , gene , immunotherapy , tumor associated antigen
Protein analyses were performed in 15 cyst fluids (CF) from mature teratoma (TD) and in 15 corresponding sera from 9 nonseminomatous germ cell tumor patients. Qualitatively, many similarities between the protein compositions of CF and corresponding sera were seen. Quantitative comparisons suggested free diffusion of plasma proteins into the cyst lumen in nine cases, whereas in five CF a decreased size selectivity of the blood–TD barrier was observed. From the quantitative data it was concluded that the significantly increased C CF /C serum concentration ratios for the tumor markers alpha‐fetoprotein (8/14), human chorionic gonadotropin (3/14), and carcinoembryonic antigen (13/13) as well as for lysozyme (12/13), ferritin (12/13), and fibronectin (3/6) were either due to local synthesis or to concentrating properties of the TD cells. The results of the current study encourage further research for new tumor‐associated proteins in cyst fluids.