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Long‐term effects of cranial irradiation on endocrine function in children with brain tumors a prospective study
Author(s) -
Duffner Patricia K.,
Cohen Michael E.,
Voorhess Mary L.,
Macgillivray Margaret H.,
Brecher Martin L.,
Panahon Alvin,
Gilani Behzad B.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19851101)56:9<2189::aid-cncr2820560909>3.0.co;2-i
Subject(s) - medicine , endocrine system , prolactin , hormone , growth hormone deficiency , urinary system , growth hormone , prospective cohort study , thyroid , endocrinology
This study prospectively evaluated the endocrine function of 11 children treated with cranial irradiation (CRT) for brain tumors. All tumors were remote from the hypothalamic‐pituitary axis. Children were studied before treatment and at 3, 6, and 12 months after the completion of CRT. T4, thyroid‐stimulating hormone, prolactin, plasma cortisol, and urinary follicle‐stimulating hormone and lueteinizing hormone values were normal before and after treatment in all patients. Growth hormone (GH) deficiency was identified in 0 of 7 patients before treatment, in 2 of 7 patients 3 months post‐CRT, in 9 of 11 patients 6 months post‐CRT, and in 7 of 8 patients 12 months post‐CRT. Growth deceleration was identified in five of seven prepubertal patients. GH deficiency is an extremely common sequelae of CRT, beginning as early as 3 months after the completion of CRT. The deficit is progressive over time.