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Prognostic significance of nuclear DNA content in small cell carcinoma of the lung
Author(s) -
Abe Shosaku,
Makimura Shiro,
Itabashi Koichi,
Nagai Tatsuo,
Tsuneta Yasuhiro,
Kawakami Yoshikazu
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19851015)56:8<2025::aid-cncr2820560823>3.0.co;2-c
Subject(s) - nuclear dna , medicine , feulgen stain , carcinoma , lung cancer , lung , pathology , dna , cancer , small cell carcinoma , gastroenterology , oncology , biology , staining , genetics , gene , mitochondrial dna
The relationship between the nuclear DNA histogram patterns of tumor cells obtained by brushing via bronchoscopy and the survival time of 39 patients with small cell carcinoma of the lung was investigated. The brushing smears were stained by a modified Feulgen method. The nuclear DNA content was measured at 550 nm using a microspectrophotometer. The DNA histogram pattern was classified into type I, which contained a higher proportion of G 0 G 1 ‐phase cells, and type II, which contained a higher proportion of S, G 2 M‐phase cells. The median survival times for the patients with limited disease of type I, type II and the patients with extensive disease of type I, type II were 17.2 months, 10.2 months, 10.0 months, and 5.6 months, respectively. Patients with limited disease of type I had a significantly longer survival time than patients with limited disease of type II. A distinct correlation was found between the histogram pattern and the survival of the patients. These results indicated that the nuclear DNA histogram pattern may be an indicator to allow speculation as to the prognosis of patients with small cell carcinoma of the lung. Cancer 56: 2025‐2030, 1985.