Premium
Preliminary results of a phase I/II study With Pi‐Meson (Pion) treatment for bladder cancer
Author(s) -
Studer Urs E.,
Von Essen Carl F.,
Enderli JeanBernard,
Bodendörfer Gerd,
Zingg Ernst J.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19851015)56:8<1943::aid-cncr2820560809>3.0.co;2-b
Subject(s) - pion , medicine , bladder cancer , clearance , cancer , radiation therapy , urology , nuclear medicine , surgery , physics , nuclear physics
Radiation therapy with negative pi‐mesons (pions) was administered to 36 patients with bladder cancer. According to a Phase I/II study, doses varied from 3000 to 3600 pion rad. Although only two complete responses were achieved among 8 evaluable patients who had predominantly papillary bladder tumors, more promising results were obtained in 22 evaluable patients who had sessile, invasive carcinomas: 19 bladders were cystoscopically and cytologically cleared of tumor after 6 months. Although the side effects during the ambulatory treatment were minimal or tolerable, a steep dose‐response curve for late side effects was observed with severe complications in 7 of 11 patients who received 3600 or more pion rad. Cancer 56: 1943‐1952, 1985.