Premium
High‐dose cytosine arabinoside‐associated pancreatitis
Author(s) -
Siemers Ross F.,
Friedenberg William R.,
Norfleet Robert G.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19851015)56:8<1940::aid-cncr2820560808>3.0.co;2-n
Subject(s) - medicine , pancreatitis , gastroenterology , abdominal pain , complication , chemotherapy , lymphoma , pancreatic disease , cytarabine , leukemia , pancreas
Thirty patients with leukemia and lymphoma have been treated at our institution with high doses of cytosine arabinoside (Ara‐C). Gastrointestinal symptoms were frequent after therapy, and 6 of the 30 patients had severe abdominal pain. Of the six, two had pancreatitis; two had normal amylase and lipase determinations; and in two, neither amylase nor lipase levels were determined. The two patients with pancreatitis are presented because this complication of high‐dose Ara‐C therapy has not been described. The authors conclude that pancreatitis can follow high‐dose Ara‐C chemotherapy and that patients with abdominal pain following this treatment be evaluated for pancreatitis. Cancer 56: 1940‐1942, 1985.