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Significance of estrogen and progesterone receptors, disease‐free interval, and site of first metastasis on survival of breast cancer patients
Author(s) -
Alanko Arto,
Hein Erkki,
Scheinin Theodor,
Tolppanen EsaMatti,
Vihko Reijo
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19851001)56:7<1696::aid-cncr2820560738>3.0.co;2-n
Subject(s) - medicine , breast cancer , oncology , estrogen receptor , metastasis , estrogen , progesterone receptor , cancer , proportional hazards model , mastectomy , endocrine system , hormonal therapy , hormone
Estrogen and progesterone receptors (ER/PR) were measured in primary tumors and metastases of 397 breast cancer patients. Survival following mastectomy was significantly longer in patients with ER and PR positive tumors, as was survival after first recurrence. The prognostic value of ER and PR was compared with such clinical factors as disease‐free interval (DFI) and the dominant site of first metastasis by Cox's regression analysis. With all the different therapy modalities long DFI was the best prognostic indicator. However, in the patient group treated with endocrine therapy, ER and PR positivity was the best prognostic indicator, suggesting that longer survival in receptor positive patients was related to the response to endocrine treatment. Cancer 56: 1696‐1700, 1985.