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TNO‐6‐induced acute renal failure. A case report
Author(s) -
Offerman Joop J. G.,
Hollema Harry,
Elema Job D.,
Koops Heimen Schraffordt,
De Vries Elisabeth G. E.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19851001)56:7<1511::aid-cncr2820560706>3.0.co;2-l
Subject(s) - medicine , infiltration (hvac) , necrosis , cisplatin , pathology , proteinuria , acute kidney injury , acute tubular necrosis , edema , renal injury , kidney , urology , chemotherapy , physics , thermodynamics
A case of fatal acute renal failure during treatment with 1,1‐diaminomethyl cyclohexane sulphato platinum II (TNO‐6) is reported. Pathologic investigation showed focal tubular necrosis with interstitial infiltration and edema. Despite the development of proteinuria no changes of the glomeruli were found, either by light or electron microscopic investigation. The pathologic changes caused by TNO‐6 are similar to those found in renal failure caused by cisplatin (CDDP). Cancer 56: 1511‐1514, 1985.