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Immunoproliferative small intestinal disease and primary small intestinal lymphoma. Relation to alpha chain protein
Author(s) -
Banisadre Mussa,
Ala Feridoon,
Modjtabai Attarod,
Dutz Werner,
Navab Farhad
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850915)56:6<1384::aid-cncr2820560628>3.0.co;2-5
Subject(s) - medicine , jejunum , malabsorption , lymphoma , gastroenterology , ileum , small intestine , mesenteric lymph nodes , pathology , alpha (finance) , surgery , spleen , construct validity , patient satisfaction
Forty‐three patients with immunoproliferative small intestinal disease and primary small intestinal lymphoma were studied prospectively. Eighteen patients in whom α‐chain protein was detected in the serum had significantly more features of malabsorption, and disease was localized more commonly in the jejunum. In all of these patients, a diffuse lymphoplasmacytic infiltrate was found in the intestine; in three patients lymphoma was found only in mesenteric lymph nodes. Twenty‐five patients with lymphoma in whom α‐chain protein failed to be detected had significantly more features of intestinal obstruction, and disease was found more commonly in the ileum. Five of these patients had lymphoma associated with a diffuse mucosal infiltrate that was indistinguishable from the first group. In patients available for follow‐up, no difference was found in cumulative survival over 30 months in the two groups, with approximately 40% mortality at 6 months.