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Aziridinylbenzoquinone in recurrent, progressive glioma of the central nervous system. A phase ii study by the illinois cancer council
Author(s) -
Haid Max,
Khandekar Janardan D.,
Christ Miriam,
Johnson Carole M.,
Miller Stephen J.,
Locker Gershon Y.,
Merrill John M.,
Reisel Herbert,
Hatfield Alan,
Lanzotti Victor,
Stiff Patrick,
Shaw John,
Krauss Stuart,
Showel John,
Blough Richard,
Gordon Leo
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850915)56:6<1311::aid-cncr2820560615>3.0.co;2-v
Subject(s) - medicine , progressive disease , radiation therapy , glioma , chemotherapy , cancer , surgery , lesion , cancer research
Aziridinylbenzoquinone (AZQ) was studied in a Phase II protocol for persons with glioma of the central nervous system (CNS) recurrent or progressive after surgery and radiotherapy. Patients received AZQ, 30 mg/m 2 intravenously every 3 weeks if previously untreated or 27.5 mg/m 2 if previously exposed to cytotoxic drugs. Partial response was defined as a reduction of at least 50% reduction in the product of the two longest perpendicular diameters of the indicator lesion persisting for a minimum of 28 days. Twenty‐eight patients are evaluable for response at this time. Objective response (OR) occurred in four (14.3%): two complete and two partial. Stabilization of disease (SD) was seen in 7 (25.0%). Median survival, in weeks, was >46.0 for responders, 41.7 for SD, and 19.3 for those with progressive disease. The survival experiences are significantly different ( P = 0.030 [Breslow]). The OR rate was 21.1% in 19 without prior chemotherapy and 0% in 9 previously treated patients. There were two AZQ‐related deaths in patients with prior exposure to nitrosoureas (1 CNS hemorrhage; 1 aspiration pneumonia). One patient had an anaphylactic reaction. Three patients whose tumor initially increased in size subsequently had marked tumor shrinkage. AZQ is an active agent that must be used with added caution in patients who have received nitrosoureas. Initial tumor enlargement may precede response. Although response appears to prolong survival, the correlation between stabilization of disease and survival is not well‐defined.