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Therapeutic implications of the natural history of advanced cervical cancer as defined by pretreatment surgical staging
Author(s) -
Potish Roger A.,
Twiggs Leo B.,
Okagaki Takashi,
Prem Konald A.,
Adcock Leon L.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850815)56:4<956::aid-cncr2820560442>3.0.co;2-u
Subject(s) - medicine , natural history , cervical cancer , radiation therapy , lymph node , lymphatic system , surgery , sentinel node , cancer , radiology , breast cancer , pathology
From 1978 to 1983, 112 women with advanced cervical carcinomas received radiotherapy after pretreatment surgical staging. Five‐year actuarial relapse‐free survival rates were a strong function of lymphatic spread: 40% with periaortic node metastases, 50% with pelvic node metastases, and 84% without node metastases. Primary treatment failure had a distant component in 75% of recurrences (50% of recurrences with negative nodes and 85% of recurrences with positive nodes). It was concluded that adjuvant systemic therapy is necessary to substantially raise the probability of cure.