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Intra‐arterial infusion chemotherapy as an induction therapy in multidisciplinary treatment for locally advanced breast cancer. A long‐term follow‐up study
Author(s) -
Koyama Hiroki,
Nishizawa Yukio,
Wada Tomio,
Kabuto Toshiyuki,
Shiba Eiichi,
Iwanaga Takeshi,
Terasawa Toshio,
Wada Akira
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850815)56:4<725::aid-cncr2820560404>3.0.co;2-3
Subject(s) - medicine , chemotherapy , breast cancer , cancer , induction chemotherapy , mastectomy , lymph node , surgery , oncology
A multidisciplinary treatment including intra‐arterial infusion chemotherapy as an induction therapy was administered to 55 patients with locally advanced breast cancer. Intra‐arterial chemotherapy conducted preoperatively produced marked responses in primary and lymph node lesions with 78% complete + partial response (CR + PR), subsequently permitting extended radical mastectomy. Histologic examination of resected specimens also revealed that 33% of the patients had no viable cancer cells remaining in their lesions. Five‐year and 10‐year survival rates were 57% and 41%, respectively, compared with 24% and 18%, respectively for the 17 patients of historic control. Patients showing better local responses to intra‐arterial chemotherapy had longer survival time with less frequent local recurrences. Intra‐arterial chemotherapy is an effective modality for the treatment of locally advanced breast cancer.