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Bone marrow morphologic changes after combination chemotherapy including VP‐16
Author(s) -
Adelstein David J.,
Hines John D.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850801)56:3<467::aid-cncr2820560309>3.0.co;2-0
Subject(s) - medicine , bone marrow , chemotherapy , biopsy , combination chemotherapy , pathology , cancer , lung cancer , cytotoxic t cell , biology , biochemistry , in vitro
Bone marrow aspirates and biopsy specimens were examined from seven patients with small cell lung cancer. All patients had received recent combination chemotherapy including VP‐16. No correlation between marrow biopsy cellularity and hematologic toxicity could be established. However, an unusual combination of morphologic changes was seen. This included an initial rapid increase in the M:E ratio, interference with cell division, and eventual cell death. There was little evidence of mitotic arrest or megaloblastosis. These changes are consistent with the known mechanism of action of VP‐16, the only agent given to all patients. The small sample size and the unknown contributions of the other cytotoxic agents administered allow only limited conclusions.