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Hepatic irradiation in the management of metastatic hormone‐secreting tumors
Author(s) -
Tochner Zelig A.,
Kinsella Timothy J.,
Glatstein Eli
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850701)56:1<20::aid-cncr2820560105>3.0.co;2-9
Subject(s) - medicine , hormone , radiation therapy , hormone therapy , toxicity , natural history , external beam radiotherapy , radiology , oncology , cancer , brachytherapy , breast cancer
Three patients with extensive liver metastases from hormone‐secreting tumors were treated with external beam radiation therapy to palliate signs and symptoms of tumor mass and/or hormone secretion. These patients experienced an objective response of 3, 14, and 24 months duration, respectively, as measured by plasma hormone levels and/or computed tomography (CT) scanning. Using conventional fractionation, a dose of 2400 to 3000 rad was delivered without significant acute or late toxicity. Although these tumors have a long natural history (many years), even after the development of liver metastases, radiation therapy can provide effective palliation and should be considered as a therapeutic option.