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Angiotensin converting enzyme. A possible histologic indicator for human renal cell carcinoma
Author(s) -
Takada Yasuharu,
Hiwada Kunio,
Yokoyama Masayoshi,
Ochi Kenji,
Takeuchi Masafumi,
Kokubu Tatsuo
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850701)56:1<130::aid-cncr2820560120>3.0.co;2-y
Subject(s) - pathology , medicine , renal cell carcinoma , antibody , carcinoma , kidney , immunofluorescence , cell , renin–angiotensin system , angiotensin converting enzyme , lung , biology , immunology , biochemistry , blood pressure
Angiotensin converting enzyme (ACE) was studied in specimens of human renal cell carcinoma by indirect immunofluorescence using rabbit antibody to human kidney ACE and fluorescein‐labeled goat antibody to rabbit immunoglobulin. ACE was demonstrated in the cells of all renal cell carcinomas from 10 patients and in the cultured cells set up from 4 of them, but not in any cells of 12 extrarenal carcinomas of prostate, lung, and alimentary tract. These results suggest that immunohistologic detection of ACE is of value in the histologic diagnosis of renal cell carcinoma.