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Histiocytoid hemangioma of the heart with peripheral eosinophilia
Author(s) -
Kuo TsengTong,
Hsueh Swei,
Su IhJen,
Chen JongShuin,
GonzalezCrussi Frank
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850615)55:12<2854::aid-cncr2820551225>3.0.co;2-f
Subject(s) - pathology , basal lamina , medicine , pleomorphism (cytology) , eosinophilia , immunostaining , eosinophilic , myxoma , hemangioma , immunohistochemistry , ultrastructure , cardiology
A histiocytoid hemangioma of the heart is reported, which was found incidentally in a man with unusually high eosinophilia. The eosinophilia subsided dramatically following removal of the tumor. The “histiocytoid” or the “epithelioid” appearance of the tumor cells and the presence of vacuolated cells were the characteristic microscopic features. The endothelial origin of this tumor was verified by positive immunostaining for factor VIII‐related antigen and ultrastructural demonstration of intracytoplasmic lumen formation, abundant cytoplasmic filaments, pinocytotic vesicles, and prominent basal lamina. The presence of mitotic activity, cellular pleomorphism, and tumor necrosis raised the possibility of its malignant potential. The occurrence of this tumor in the heart may be mistaken for a myxoma clinically and a metastatic carcinoma pathologically.