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Intramedullary spinal cord germinoma producing hcg and precocious puberty in a boy
Author(s) -
Hisa Shigeo,
Chikaoka Hideo,
Morinaga Shojiro,
Ojima Motoko,
Sasano Nobuaki,
Kobayashi Yasuko
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850615)55:12<2845::aid-cncr2820551223>3.0.co;2-j
Subject(s) - medicine , metrizamide , laminectomy , germinoma , spinal cord , intramedullary rod , precocious puberty , surgery , chemotherapy , radiation therapy , human chorionic gonadotropin , biopsy , pinealoma , gonadotropin , radiology , myelography , hormone , psychiatry
Extremely high concentrations of human chorionic gonadotropin in the cerebrospinal fluid were found in a 5‐year‐old boy presenting sexual precocity and leg pain. An intramedullary spinal cord tumor was revealed by myelogram and metrizamide computerized tomography, and a biopsy specimen taken at laminectomy. Histologically, the tumor showed germinoma with syncytiotrophoblastic giant cells. The tumor remitted for 5 months after irradiation of 3500 rad and chemotherapy, but recurred in spite of adding 7500 rad and more aggressive chemotherapy. No relapse has been seen for 1 year after amputation of the spinal cord at the T7 level.