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Hepatolithiasis associated with cholangiocarcinoma. Possible etiologic significance
Author(s) -
Koga Akitoshi,
Ichimiya Hitoshi,
Yamaguchi Kohji,
Miyazaki Kohji,
Nakayama Fumio
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850615)55:12<2826::aid-cncr2820551219>3.0.co;2-1
Subject(s) - hepatolithiasis , medicine , bile duct , intrahepatic bile ducts , gastroenterology , pathology , hyperplasia , duct (anatomy) , hepatectomy , surgery , resection
Three cases of primary bile duct carcinomas (cholangiocarcinomas) were found among 61 cases of hepatolithiasis. Cholangiocarcinoma arose from the extrahepatic bile duct in one and from the dilated intrahepatic bile duct in two patients. Hyperplasia of the columnar cells was often present. These hyperplastic epithelial cells often show papillomatous or adenomatous pattern, which are frequently associated with the presence of stones and the contaminated bile, and may show malignant changes leading to the development of cholangiocarcinoma.