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Radiofrequency hyperthermia as adjuvant therapy following surgical resection of an experimental malignant neoplasm
Author(s) -
Dalfen Richard,
Calhoun Kevin,
Gilas Tom,
Mathews Tina,
Falk Michael,
Moffat Frederick L.,
Makowka Leonard,
Rotstein Lorne E.,
Langer Jacob C.,
Venturi David,
Laing David,
Falk Judy A.,
Falk Rudolf E.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850601)55:11<2737::aid-cncr2820551137>3.0.co;2-f
Subject(s) - medicine , adjuvant , adjuvant therapy , surgery , hyperthermia , mitomycin c , subcutaneous injection , neoplasm , chemotherapy , pathology , oncology
Local recurrence after radical surgery is a major problem with many primary solid cancers. The use of radiofrequency hyperthermia (RFHT) as adjuvant therapy to surgery was explored in the Fischer bladder carcinoma (FBCa)/F344 rat tumor system. After subcutaneous innoculation of 34 rats with 10 6 FBCa cells in suspension, RFHT was administered to 17 animals on days 1, 5, 8, and 12. The development of palpable tumors was delayed but not prevented, and tumor growth was retarded in RFHT‐treated animals. In another experiment 40 rats were innoculated by subcutaneous trocar injection with a 1 mm 3 piece of FBCa. After tumor excision on day 17, adjuvant therapy (untreated control, mitomycin C, RFHT, or RFHT plus mitomycin C) was started on day 20 (10 rats/treatment). The 20 RFHT‐treated rats had only 1 incisional recurrence as compared to 9 recurrences in sham‐heated rats ( P < 0.005). The authors conclude that RFHT has considerable value as adjuvant therapy to surgery in these tumors. Additional studies of RFHT as adjuvant treatment after surgical excision of tumors are planned.