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Estrogen and progestin receptors in human prostatic carcinoma
Author(s) -
Wolf Richard M.,
Schneider Sara L.,
Pontes J. Edson,
Englander Lenore,
Karr James P.,
Murphy Gerald P.,
Sandberg Avery A.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850515)55:10<2477::aid-cncr2820551028>3.0.co;2-g
Subject(s) - prostate , medicine , hyperplasia , estrogen receptor , receptor , estrogen , progestin , carcinoma , urology , pathology , endocrinology , cancer , breast cancer
Cytosol receptors for estrogens (ER) and progestins (PR) were assayed in human prostatic carcinoma (CaP) and benign prostatic hyperplasia (BPH). Specimens were obtained from either the peripheral or the periurethral zone of the prostate. Stringent criteria were used to identify and measure 7‐8S specific receptor using sucrose gradient analysis in a vertical tube rotor. Progesterone receptor was found in 14 BPH samples assayed and in 12 of 13 prostate cancers. In contrast, the 7‐8S estrogen receptor was found in none of the nine benign samples assayed and in all prostate cancers. BPH samples were taken from either peripheral or periurethral zones and gave similar results. The histology of individual specimens did not correlate with either the ER or PR present, and, in the cancers, there was no correlation between the pathologic stage or the Gleason score and receptor content.