Premium
Carcinoembryonic antigen and steroid receptors in the cytosol of carcinoma of the breast. Relationship to pathologic and clinical features
Author(s) -
Schwartz Mary R.,
Randolph Rebecca L.,
Panko Walter B.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850515)55:10<2464::aid-cncr2820551026>3.0.co;2-w
Subject(s) - carcinoembryonic antigen , medicine , receptor , pathology , estrogen receptor , carcinoma , hormone , hormone receptor , breast cancer , estrogen , mammary gland , progesterone receptor , oncology , endocrinology , cancer
Cytosols of 159 primary breast carcinomas were assayed for estrogen and progesterone receptors and 60 of these for carcinoembryonic antigen (CEA). The relationships of pathologic and clinical features previously shown to be of prognostic significance and the biochemical parameter measured were examined. It was found that degree of histologic differentiation was significantly related to receptor status. There were significant inverse relationships between estrogen receptor and lymphocytic infiltrate as well as tumor necrosis. Relationships between estrogen, but not progesterone, receptor and patient age, menstrual status, and race existed. Cytosol CEA, on the other hand, related only to pathologic stage and not to histologic differentiation and other pathologic variables. Therefore, steroid receptors and CEA appear to provide information about different biologic characteristics of a carcinoma. Furthermore, the information provided by CEA appears to be independent of many known pathologic, clinical, and biochemical prognostic indicators.