Premium
Is hypereosinophilic syndrome a malignant disease?
Author(s) -
Goh K. O.,
Ho F. S. C.,
Tso S. C.,
Ma J.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850515)55:10<2395::aid-cncr2820551016>3.0.co;2-u
Subject(s) - hypereosinophilia , medicine , hypereosinophilic syndrome , eosinophilic , pathology , abdominal mass , bone marrow , biopsy , eosinophilia , leukemia
A patient with an abdominal mass for 4 years developed hypereosinophilia and weight loss. Bone marrow aspirations and biopsy specimens showed hypercellularity of eosinophils. No cause for hypereosinophilia was found. Biopsy specimens of several organs, including the abdominal mass, showed eosinophilic infiltration with reactive fibrosis in some. Cytogenetic studies of the bone marrow before treatment with cytoxic drugs showed chromosomal abnormalities. Several of these have been reported in association with acute or eosinophilic leukemias. Based upon these findings, the authors believe that the patient had eosinophilic leukemia and that the abdominal mass probably was an eosinophilic chloroma.