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Malignant large cell lymphoma of B‐cell type with multilobated nuclei. Report of a case and review of the literature
Author(s) -
Parfrey Nollaig A.,
Mann Risa B.,
Selonick Stuart E.,
Beschorner William E.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850501)55:9<1913::aid-cncr2820550914>3.0.co;2-r
Subject(s) - lymphoma , monoclonal antibody , antigen , antibody , pathology , lymphocyte , b cell , immune system , monoclonal , large cell , medicine , immunology , biology , cancer , adenocarcinoma , genetics
Malignant lymphomas with multilobated nuclei are rare, recently recognized neoplasms of the immune system initially thought to be of T‐cell type. Reported is a case of large cell lymphoma with multilobated nuclei in which immunologic marker studies demonstrated that the neoplastic cells had characteristics of B‐lymphocytes. The neoplastic cells possessed surface and cytoplasmic immunoglobulin of the IgG, lambda type, and stained diffusely with monoclonal antibodies to B1, Leu‐10 and OKIal antigens and focally with anti‐B2. The lymphoma cells did not react with monoclonal antibodies directed against T‐cells and monocytes/granulocytes. As documented here with multiple monoclonal antibody lymphocyte markers, the multilobated lymphoma can have a B‐cell phenotype as well as the cell phenotype described previously. Thus, even the unique finding of multilobated nuclear morphologic features is unreliable in predicting the lymphocyte lineage.