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Clinicopathologic and immunologic characteristics of non‐Hodgkin's lymphomas presenting in the orbit. A report of eight cases
Author(s) -
Lazzarino M.,
Morra E.,
Brusamolino E.,
Pagnucco G.,
Bernasconi C.,
Rosso R.,
Castello A.,
Ghisolfi A.,
Tafi A.,
Zennaro G.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850501)55:9<1907::aid-cncr2820550913>3.0.co;2-j
Subject(s) - medicine , pathology , subclinical infection , orbit (dynamics) , presentation (obstetrics) , homing (biology) , disease , radiology , biology , engineering , aerospace engineering , ecology
Of 325 consecutive cases of non‐Hodgkin's malignant lymphomas, 8 patients (2.4%) showed orbital presentation. The clinicopathologic and immunologic analysis of the eight patients revealed characteristic biologic features. Despite the apparently isolated orbital presentation, all cases had subclinical systemic disease. Seven of the eight cases exhibited lymphoplasmacytic/cytoid features, with concurrent type II cryoglobulinemia in five of them. In addition, during their clinical course, five patients showed single or multiple subcutaneous nodules with the same histologic and immunologic pattern as the orbital tumor. This study demonstrates that most orbital lymphomas share particular clinicopathologic and immunologic features, suggesting an origin from a B‐cell subset with preferential homing to orbital tissues and subcutis.