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Nephrotic syndrome in two patients with cured Hodgkin's disease
Author(s) -
Shapiro Charles M.,
Laan Burton F. Vander,
Jao Wellington,
Sloan Dennis E.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850415)55:8<1799::aid-cncr2820550827>3.0.co;2-s
Subject(s) - medicine , nephrotic syndrome , disease , nephrosis , malignancy , lymphoma , complication , glomerulonephritis , lesion , pathology , kidney
Two cases of lipoid nephrosis (minimal change glomerulonephritis) in patients cured of Hodgkin's disease are reported and the literature is reviewed. Cases reported to date have shown a close temporal relationship between this renal lesion and the presence of Hodgkin's disease. The patients reported are 11 and 9 years without evidence of active malignancy after successful treatment for Hodgkin's disease. Each had abnormal immunologic parameters, depressed T 4 (helper) cells and increased T 8 (suppressor) cells, which may predispose to the development of the nephrotic syndrome. However, the advent of this complication is not necessarily a harbinger of recurrent lymphoma.