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Human papillomavirus type 16 related DNA in an anaplastic carcinoma of the lung
Author(s) -
Stremlau Armin,
Gissmann Lutz,
Ikenberg Hans,
Stark Marlies,
Bannasch Peter,
Hausen Harald Zur
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850415)55:8<1737::aid-cncr2820550820>3.0.co;2-o
Subject(s) - medicine , sex organ , lung cancer , carcinoma , anaplastic carcinoma , pathology , dna , biopsy , cervical cancer , cancer , biology , genetics
Twenty‐four biopsy specimens from various histologic types of human carcinomas in the lung were analyzed for the presence of human papillomavirus (HPV) DNA. DNA from the individual specimens was tested for the presence of homologous sequences to HPV genotypes 1, 2, 4, 8, 9, 10, 11, 13, 16 and 18. One anaplastic carcinoma in the lung contained multiple copies of DNA hybridizing under stringent conditions to HPV 16 DNA. The latter DNA has been found to be frequently associated with human genital cancer (cervical, penile, and vulval cancer) and genital Bowen's disease. The HPV 16 positive lung tumor originated from a 61‐year‐old female patient who underwent hysterectomy due to cervical cancer 9 years earlier.