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A cell kinetic study on medulloblastomas
Author(s) -
Hoshino Takao,
Kobayashi Shu,
Townsend Jeannette J.,
Wilson Charles B.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850415)55:8<1711::aid-cncr2820550816>3.0.co;2-r
Subject(s) - medulloblastoma , medicine , radiation therapy , biopsy , cerebellum , pathology , nuclear medicine , surgery
The cell kinetics of medulloblastoma were studied to define characteristic proliferation for comparison with other neuroectodermal tumors. Four patients with cerebellar medulloblastoma received 3 H‐thymidine intravenously 1 to 2 days before surgery. Biopsy specimens from each tumor were processed for autoradiography. The respective average labeling indices were 14.4%, 14.1%, and 11.2% in the three midcerebellar medulloblastomas and 8.0% in the cerebellar hemispheric medulloblastoma. The mean survival time with various treatments including radiation therapy before or after the study in these four patients was 6 years (range, 3–9 years). In contrast, patients with malignant gliomas that had a labeling index greater than 5% died within 1 year. This difference in survival was attributed to the greater sensitivity of medulloblastoma to radiation therapy.