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Combined radiation and chemotherapy for locally advanced transitional cell carcinoma of the urinary bladder
Author(s) -
Jakse Gerhard,
Frommhold Herman,
Nedden Dieter Zur
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850415)55:8<1659::aid-cncr2820550808>3.0.co;2-y
Subject(s) - medicine , transitional cell carcinoma , radiation therapy , toxicity , urology , chemotherapy , urinary bladder , urinary system , carcinoma , surgery , transitional cell , bladder cancer , cancer
A prospective study was performed on 22 patients with locally advanced transitional cell carcinoma of the urinary bladder to evaluate the toxicity and efficacy of an integrated treatment with cis‐diamminedichloroplatinum (1.6 mg/kg body weight every 3 weeks for four cycles) and 60 G cobalt 60 or 18 MEV photons. Local and systemic toxicity caused by this treatment schedule was minor. Late sequelae consisted of contracted bladder in three patients. The rate of tumor‐free bladders after a mean follow‐up of 14 months was 17 of 22. Distant metastases occurred in three patients. Local recurrence of superficial tumor elsewhere in the bladder was observed in two patients. Six patients died 4 to 10 months after initiation of the integrated therapy, three of these without evidence of disease.