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Acquisition of a Philadelphia chromosome concomitant with transformation of a refractory anemia into an acute leukemia
Author(s) -
Smadja N.,
Krulik M.,
De Gramont A.,
Brissaud P.,
Debray J.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19850401)55:7<1477::aid-cncr2820550710>3.0.co;2-a
Subject(s) - acute myeloblastic leukemia , clone (java method) , medicine , acute leukemia , acute myelomonocytic leukemia , refractory (planetary science) , karyotype , concomitant , oncology , leukemia , immunology , cancer research , chromosome , biology , genetics , dna , gene , astrobiology
The authors present a case of Philadelphia (Ph 1 ) positive acute myeloblastic leukemia (AML) following a refractory anemia with excess of blasts (RAEB) that had been Ph 1 ‐negative for 17 months. During the transformation of RAEB into AML, the Ph 1 was discovered in 100% of the examined cells. With therapy a partial remission was obtained, during which some 46,XY cells reappeared mixed with Ph 1 cells along with a new clone: 47,XY,+11 originating from a Ph 1 ‐negative cell. During the terminal blast crisis, the karyotype returned to 46,XY,Ph 1 . The AML lasted 21 months. The authors discuss: (1) the significance of Ph 1 ‐positive AML with a review of the literature; (2) the de novo acquisition of a Ph 1 during the course of a blood disorder; and (3) the meaning of a second abnormal clone originating from 46,XY cells.